Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes

• DOI: 10.3389/fmed.2022.822806
• Publication Date: 2022-03-01T04:49:28Z
• Authors: Yili Chen; Yuandong Liao; Qiqiao Du; Chunliang Shang; Shuhang Qin; Kaping Lee; Qiaojian Zou; Junxiu Liu; Shuzhong Yao
• Keywords: Pyroptosis; Gene signature

Endometrial cancer (EC) is one of the most common gynecological malignancies in women, accompanied by increasing incidence and decreasing age onset. Pyroptosis plays an important role occurrence development malignant tumors. However, relationship between pyroptosis-related genes tumor prognosis remains unclear. In this study, analyzing expression levels survival data 33 Cancer Genome Atlas (TCGA) normal samples samples, we obtained six prognostic differentially expressed (DEGs). Then, through least absolute shrinkage selection operator (LASSO) regression analysis, a gene signature composed (GPX4, GSDMD, GSDME, IL6, NOD2 PYCARD) was constructed divided patients into high- low-risk groups. Subsequently, Kaplan-Meier (KM) plot, receiver operating characteristic (ROC) curve principal component analysis (PCA) two cohorts demonstrated that efficient independent indicator. The enrichment immune infiltration indicated high-risk group generally has lower infiltrating cells less active function. short, validated to predict EC, which correlated proposed help precise diagnosis therapy EC.