Case Report: Pure Red Cell Aplasia Caused by Refractory Parvovirus B19 Infection After Pancreas Transplantation Alone

• DOI: 10.3389/fmed.2022.849783
• Publication Date: 2022-03-16T05:48:46Z
• Authors: Jørn Petter Lindahl; Regine Barlinn; Ingerid Weum Abra...; Signe Spetalen; Karsten Midtvedt; Trond Jenssen
• Keywords: Medicine (General); immunosuppression; parvovirus B19; pure red cell aplasia (PRCA); pancreas transplant alone; 610; type 1 diabetes (T1D); anemia; 3. Good health; 03 medical and health sciences; R5-920; 0302 clinical medicine; 616; Medicine

A multidisciplinary team of doctors is in charge or involved the follow-up patients who undergo solid organ transplantation (SOT). Immunosuppressive drugs are required after SOT, some potential unwanted side effects can be difficult to detect, and physicians must aware pitfalls. We report a case recipient with brittle type 1 diabetes experienced severe refractory anemia pancreas alone (PTA). Despite broad diagnostic approach for anemia, diagnosis was delayed. The patient had normocytic normochromic reticulocytopenia marked reduction absence erythroid precursors bone marrow, compatible pure red cell aplasia (PRCA). Analyses serological parvovirus B19 anti-IgM anti-IgG antibodies, including PCR, were initially inconclusive/negative. infection confirmed marrow biopsy immunohistochemical staining B19. retrospective analysis revealed an early post-transplant primary infection. successfully treated intravenous immunoglobulin (IVIg) therapy. There risk delay less common types following SOT. Parvovirus infection-associated PRCA curable SOT recipients should actively considered persistent low reticulocytes.