Patient with suspected co-infection of hemorrhagic fever with renal syndrome and malaria: a case report

• DOI: 10.3389/fmed.2024.1341015
• Publication Date: 2024-05-01T05:01:25Z
• Authors: Han-Dong Zhao; Hong-Bo Qian; Ze-Kun Wang; Rui-Kang Ren; Tong-Bo Yu; Hong-Li Liu
• Keywords: Chills; Oliguria; Leukocytosis; Polyuria

Background Hemorrhagic fever with renal syndrome (HFRS) is a natural epidemic disease that can be caused by the Hantaan virus (HTNV). Malaria plasmodium and transmitted mosquito bite. The similar manifestations shared these disorders pose challenge for clinicians in differential diagnosis, particular, coupled false-positive serological test. Case presentation A 46-year-old man was admitted chills over 10 days suspected of being co-infected HFRS malaria due to history travel malaria-endemic areas positive HTNV-immunoglobulin M (IgM) Although leukocytosis, thrombocytopenia, injury, lymphocytosis, overexpression interleukin-6, procalcitonin were observed during hospitalization, hypotensive, oliguria, polyuria phases course not observed. Instead, typical symptoms found, including progressive decrease erythrocytes hemoglobin levels signs anemia. Furthermore, because patient had no exposure endemic areas, an HTNV-infected rodent, or HTNV-IgG test, false tests IgM various factors, coinfection ruled out. Conclusion Misdiagnosis easily induced particular test which influenced factors. combination health history, epidemiology, physical examination, precise application specific examinations involving conventional laboratory parameters as well well-accepted methods such immunochromatographic (ICG) real-time reverse transcription-polymerase chain reaction (PCR), Western blot (WB), acquaintance will contribute diagnosis clinical treatment.