Myeloid-derived suppressor cells exhibit distinct characteristics in bone marrow and blood of individuals with diffuse large B-cell lymphoma

• DOI: 10.3389/fmed.2024.1515097
• Publication Date: 2025-01-29T07:00:05Z
• Authors: Paris Efstratiou; Athina Damianaki; Aglaia Kavidopoulou; Polymnia Ioannidou; Effrosyni Markaki; Ioannis Moysis Sk...; Electra Tsagliotis; Vasilia Kaliafentaki; Angelos Mattheakakis; Maria Ximeri; Eleftherios Manouras; Matthieu Lavigne; Panayotis Verginis; Christina Kalpadakis
• Keywords: Myeloid-derived Suppressor Cell

Antitumor immune surveillance is the key feature of tumour progression and response to treatment in various malignancies, such as lymphomas. Myeloid derived suppressor cells (MDSCs) are bone marrow (BM)-derived with potent suppressive properties, implicated T cell inhibition dissemination. In Diffuse Large B-cell Lymphoma (DLBCL), circulating MDSCs constitute immunosuppressive tumor microenvironment, while contribution BM disease pathogenesis remains elusive. present study we aimed evaluate both frequencies well molecular signatures blood from newly diagnosed DLBCL patients prior initiation age matched healthy donors. Circulating levels total, monocytic (M-) polymorphonuclear (PMN-) were found increased compared control, significantly blood. Transcriptomic analysis revealed different fingerprints characterize M-MDSCs, implying that exhibit their function distinct mechanisms depending on anatomical compartment. Despite MDSC did not demonstrate any significant correlation characteristics outcome, our findings propose gene expression profiling should be evaluated for potential prognostic impact. Overall, presented here, provide new insights networks operate importantly expressed by which may explored therapeutically.