Exploring the Antibiotic Resistance Burden in Livestock, Livestock Handlers and Their Non-Livestock Handling Contacts: A One Health Perspective

• DOI: 10.3389/fmicb.2021.651461
• Publication Date: 2021-04-20T06:25:09Z
• Authors: Rachel A. Hickman; Thongpan Leangapi...; Kamonwan Lunha; Jatesada Jiwakanon; Sunpetch Angkitit...; Ulf Magnusson; Marianne Sunde; Josef D. Järhult
• Keywords: Colistin; Veterinary Drugs; One Health

Antibiotics are freqeuently used in the livestock sector low- and middle-income countries for treatment, prophylaxis, growth promotion. However, there is limited information into zoonotic prevalence dissemination patterns of antimicrobial resistance (AMR) within these environments. In this study we pig farming Thailand as a model to explore AMR; 156 farms were included, comprising small-sized (<50 sows) medium-sized (≥100 farms, where bacterial isolates selectively cultured from animal rectal human fecal samples. Bacterial subjected susceptibility testing (AST), whole-genome sequencing. Our results indicate extensive sharing antibiotic genes (ARGs) by horizontal gene transfer. Resistance multiple antibiotics was observed with higher medium-scale farms. Zoonotic transmission colistin small-scale had gradient pigs handlers non-livestock contacts. We highly recommend reducing use animals’ feeds medications, especially last resort drug colistin.