Disentangling the Progression of Non-alcoholic Fatty Liver Disease in the Human Gut Microbiota

• DOI: 10.3389/fmicb.2021.728823
• Publication Date: 2021-10-13T18:23:23Z
• Authors: Tianjiao Wang; Xue-Kun Guo; Huji Xu
• Keywords: Dysbiosis; Steatohepatitis; Human Microbiome Project

Gut microbiome dysbiosis has been known to be associated with all stages of non-alcoholic fatty liver disease (NAFLD), but questions remain about microbial profiles in progression and homogeneity across NAFLD stages. We performed a meta-analysis three publicly shotgun datasets built predictive models determine diagnostic capacity. Here, we found consistently shifts stages, which co-occurrence patterns core sets new biomarkers significantly correlated were identified. Machine learning that are able distinguish patients any stage from healthy controls remained when applied other suggesting the once again. Focusing on species metabolic pathways specifically progressive increased toxic metabolites decreased protection butyrate choline contributed advanced NAFLD. further discriminating one others an average 0.86 area under curve. In conclusion, this firmly establishes generalizable taxonomic functional signatures as basis for future diagnostics