Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

• DOI: 10.3389/fmicb.2022.1067725
• Publication Date: 2023-01-10T20:42:31Z
• Authors: Jicheng Han; Xiangyu Zhu; Zihan Gao; Yan Xiao; Jinxin Zhang; Peng Wang; Jinbo Fang; Yiquan Li; Yilong Zhu; Yue Li; Ningyi Jin; Huijun Lu; Dazhuan Lin; Wenshen Liu
• Keywords: Pandemic; Strain (injury)

Influenza viruses pose a serious threat to human health, infecting hundreds of millions people worldwide each year, resulting in significant increase global morbidity and mortality. activity has declined at the onset COVID-19 pandemic, but genetic diversity B/Victoria lineage increased significantly during this period. Therefore, prevention treatment influenza B Victoria strain virus should continue attract research attention. In study, we found that Atractyloside A (AA), one effective components Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study AA not only possesses anti-influenza infection effects vivo vitro also can regulate macrophage polarization M2 type, which effectively attenuate damage caused by infection. may be an natural drug against