Comparative analysis of scalp and gut microbiome in androgenetic alopecia: A Korean cross-sectional study

• DOI: 10.3389/fmicb.2022.1076242
• Publication Date: 2022-12-12T05:37:46Z
• Authors: Da-Ryung Jung; Hye-Young Yoo; Min-Ji Kim; Vineet Singh; Sung-Ha Park; Minsoo Jeong; Byoung-Jun Park; Jae-Ho Shin
• Keywords: Cross-sectional study; Gut microbiome

Androgenetic alopecia (AGA) is a non-scarring and progressive form of hair loss occurring in both men women. Although genetic predisposition sex steroid hormones are the main causes, many factors remain unknown, various extrinsic can negatively affect lifespan hair. We investigated skin-gut axis microorganisms as potential exogenous causing AGA, through comparative analyses scalp gut microbiome individuals with without AGA Korean cohort. Using 16S rRNA gene sequencing, we characterized microbiomes 141 divided into groups by presence AGA. Alpha diversity indices were generally higher than healthy controls. These showed strong negative correlation scalp-inhabitant bacteria (Cutibacterium Staphylococcus), indicating that appearance non-inhabitant increases progresses. No significant differences observed between microbiomes. However, bacterial functional differences, such bile acid synthesis invasion epithelial cells, which related to intestinal homeostasis, observed. The networks more complex denser values network topology statistic coefficient (i.e., transitivity, density, degree centrality) unique associations Our findings reveal link former's involvement latter's development. Additionally, these results provide evidence for development cosmetics therapeutics using metabolites involved