Mechanisms of Zhenwu decoction for the treatment of renal fibrosis at various stages: What is the role of Corynebacterium?

• DOI: 10.3389/fmicb.2022.913465
• Publication Date: 2022-09-06T09:29:28Z
• Authors: Lijing Du; Yiping Zhang; Shuai Ji; Leqi Wang; Xiaoshan Zhao; Shikai Yan; Xue Xiao; Shasha Li
• Keywords: Corynebacterium; Dysbiosis

Many studies demonstrated that Zhenwu decoction (ZWD) is effective in the treatment of kidney fibrosis, whereas mechanism remains unclear. In this work, a microbiomics-based strategy was used to investigate protective effects ZWD on fibrosis. Unilateral ureteral obstruction replicate rat model renal and rats were divided into prophylactic, early, progression stages according timing administration. Feces collected perform microbiota evaluation by high-throughput 16S DNA sequencing. The results indicated Corynebacterium , Alistipes Dorea Lactonifactor highlighted as key targeted flora their biological functions related inflammation, immunity, excretion. Especially, presented significant positive correlation with concentration Cys-C, Scr, BUN. changes inflammatory cytokines (INF-γ, IL-1β, IL-4, TNF-α) immunoglobulin (IgA, IgM, IgG) confirmed beneficial Therefore, study effect against fibrosis at various disease stages, its associated re-establishing dysbiosis intestinal microbiota, reducing well regulating immune functions. particular, may be