Dynamics of Small Non-coding RNA Profiles and the Intestinal Microbiome of High and Low Weight Chickens

• DOI: 10.3389/fmicb.2022.916280
• Publication Date: 2022-06-30T05:00:35Z
• Authors: Hao Zhou; Lingyu Yang; Jinmei Ding; Ke Xu; Jiajia Liu; Wenqi Zhu; Jianshen Zhu; Chuan He; Chengxiao Han; Chao Qin; Huaixi Luo; Kangchun Chen; Yuming Zheng; Christa F. Honaker; Yan Zhang; Paul B. Siegel; He Meng
• Keywords: Holobiont

The host and its symbiotic bacteria form a biological entity, holobiont, in which they share dynamic connection characterized by symbiosis, co-metabolism, coevolution. However, how these collaborative relationships were maintained over evolutionary time remains unclear. In this research, the small non-coding RNA (sncRNA) profiles of cecum their contents measured from lines chickens that have undergone long-term selection for high (HWS) or low (LWS) 56-day body weight. results originated common founder population under same husbandry showed an association between intestinal sncRNA expression profile (miRNA, lncRNA fragment, mRNA snoRNA, snRNA) microbiota. Correlation analyses suggested some central miRNAs fragments had interactions with abundance microbial species microbiota functions. miR-6622-3p, significantly differentially expressed (DE) miRNA was correlated weight gain related bacterium, Alistipes putredinis. Our sncRNAs may be mediators interaction microbiome. This provides additional clue holobiont concepts.