Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Candida albicans Infection via Activation of Aryl Hydrocarbon Receptor

• DOI: 10.3389/fmicb.2022.934786
• Publication Date: 2022-07-18T06:33:22Z
• Authors: Zetian Wang; Liping Yin; Yue Qi; Jiali Zhang; Haiyan Zhu; Jianguo Tang
• Keywords: Intestinal epithelium; Kynurenic acid

Colonization of the intestinal tract by Candida albicans (C. albicans) can lead to invasive candidiasis. Therefore, a functional epithelial barrier is critical for protecting against C. infections. We collected fecal samples from patients with bloodstream infection and healthy people. Through flora 16sRNA sequencing metabolomic analysis, we found that resulted in significant decrease expression metabolite kynurenic acid (KynA). used repeated mouse model, established following intake 3% dextran sulfate sodium salt (DSS) 9 days, KynA, tryptophan metabolite, inhibited inflammation, promoted tight junction proteins, protected damage caused also demonstrated KynA activated aryl hydrocarbon receptor (AHR) repressor vivo vitro. Using Caco-2 cells co-cultured albicans, showed AHR, myosin light chain kinase-phospho-myosin (MLCK-pMLC) signaling pathway, tristetraprolin (TTP) alleviate inflammation. Our findings suggest which differently expressed has protective effect on epithelium, via activating could be explored provide new potential therapeutic strategies