The microbiome types of colorectal tissue are potentially associated with the prognosis of patients with colorectal cancer

• DOI: 10.3389/fmicb.2023.1100873
• Publication Date: 2023-03-21T16:55:28Z
• Authors: Yixin Xu; Jing Zhao; Yu Ma; Jia Liu; Yingying Cui; Yuqing Yuan; Chenxi Xiang; Dongshen Ma; Hui Liu
• Keywords: colorectal cancer; pathogenic bacteria; prognostic biomarkers; survival; Microbiology; tissue microbe; QR1-502; 3. Good health

As the second leading cause of cancer worldwide, colorectal (CRC) is associated with a poor prognosis. Although recent studies have explored prognostic markers in patients CRC, whether tissue microbes carry information remains unknown. Here, by assessing 533 CRC patients, we found that Proteobacteria (43.5%), Firmicutes (25.3%), and Actinobacteria (23.0%) dominated microbiota, which was different from gut microbiota. Moreover, two clear clusters were obtained clustering based on across all samples. By comparison, relative abundances Bacteroidetes cluster 1 significantly higher than those 2; while compared 1, more abundant 2. In addition, Firmicutes/Bacteroidetes ratios lower Further, 2, had relatively survival (Log-rank test, p = 0.0067). correlating patient survival, abundance dominant phyla, including Proteobacteria, Firmicutes, Bacteroidetes, patients. Besides, co-occurrence network at phylum level 2 complicated 1. Lastly, detected some pathogenic bacteria enriched promote development thus to survival. contrast, showed significant increases probiotics genera resist development. Altogether, this study provides first evidence microbiome carries can help design approaches for clinically evaluating