Comparison of the gut virus communities between patients with Crohn’s disease and healthy individuals

• DOI: 10.3389/fmicb.2023.1190172
• Publication Date: 2023-06-15T04:41:21Z
• Authors: Yuzhu Ding; Mengtian Wan; Zheng Li; Xiao Ma; Wen Zhang; Min Xu
• Keywords: Human virome

The escalating incidence of Crohn's disease (CD), a debilitating ailment that ravages individuals and their families, has become formidable issue over recent decades.In this study, fecal samples from patients with CD healthy were investigated by means viral metagenomics.The virome was analyzed some suspected disease-causing viruses described. A polyomavirus named HuPyV 5,120 base pairs (bp) found in the group. In preliminary analysis employing large T region-specific primers, it present 3.2% (1/31) 43.2% (16/37) samples. Additionally, two other anellovirus CRESS-DNA virus families patients. complete genome sequences these described respectively, phylogenetic trees have been built using anticipated amino acid proteins.Further research is required to elucidate relationship between onset development disease.