Casual effects of gut microbiota on risk of infections: a two-sample Mendelian randomization study

• DOI: 10.3389/fmicb.2023.1284723
• Publication Date: 2023-10-10T06:13:33Z
• Authors: Beibei Lyu; Jinghang Ma; Yongyu Bai; Zhen Feng
• Keywords: Mendelian Randomization; Casual; Mendelian inheritance; Gut microbiome; Gut bacteria

The correlation between gut microbiota and infections has garnered significant attention in previous studies; nevertheless, our understanding of the causal relationships mechanisms specific microbial species remains limited.This study aimed to employ Mendelian randomization (MR) using single-nucleotide polymorphisms (SNPs) genome-wide association (GWAS) data European ancestry explore genetic-level distinct types susceptibility infections. Our analysis encompassed three prevalent infections: intestinal infections, pneumonia, urinary tract while concurrently examining various microbiota.We identified 18 protective microbiotas alongside 13 associated with increased infection risk. Particularly noteworthy are certain communities capable producing butyrate, such as Ruminococcaceae Lachnospiraceae families, which exhibited both favorable unfavorable effects. Additionally, we observed a few linked susceptibility, including ErysipelotrichaceaeUCG003 (OR = 0.13, 95% CI: 0.054-0.33, p 1.24E-05), Collinsella 3.25, 2.00-5.27, 1.87E-06), NB1n 1.24, 1.09-1.40, 1.12E-03).This reveals complex findings could potentially offer new avenues for exploring prevention treatment strategies infectious diseases.