Interactions and effects of a stannous-containing sodium fluoride dentifrice on oral pathogens and the oral microbiome

• DOI: 10.3389/fmicb.2024.1327913
• Publication Date: 2024-02-15T12:06:48Z
• Authors: Danyan Chen; Dillon Chew; Qianfeng Xiang; TzeHau Lam; Yajie Dai; Jiquan Liu; Lijiang Wang; Tao He; Ross Strand; Xiaolan Zhang; Linda Lim; Jian Xu; Yunming Shi; Weili Dong
• Keywords: Dentifrice; Oral Microbiome; Sodium fluoride

Numerous studies have investigated the effects of stannous ions on specific microbes and their efficacy in reducing dental plaque. Nonetheless, our understanding impact oral microbiome is still a subject ongoing exploration. Therefore, this study sought to evaluate stannous-containing sodium fluoride dentifrice comparison zinc-containing control group intact, healthy biofilms. Utilizing novel 2bRAD-M approach for species-resolved metagenomics, FISH/CLSM with probes targeting periodontal caries associated species alongside Sn 2+ Zn ions, we collected analyzed situ biofilms from 15 generally individuals measurable plaque treated dentifrices elucidate variations microbial distribution. Although significant shifts upon treatment were not observed, use primarily led an increase health-associated commensal decrease pathogenic species. Notably, analysis highlighted marked reduction representative periodontitis following dentifrice, as opposed group. Additionally, intracellular imaging reflected colocalization P. gingivalis but other In contrast, exhibited non-specific binding, thus suggesting that could exhibit selective binding toward Altogether, results demonstrate help maintain by preferentially certain bacteria reverse dysbiosis underscores importance continual usage such products preventive measure diseases maintenance health.