Function and therapeutic prospects of next-generation probiotic Akkermansia muciniphila in infectious diseases

• DOI: 10.3389/fmicb.2024.1354447
• Publication Date: 2024-02-06T05:04:57Z
• Authors: Lifeng Li; Mingchao Li; Yihua Chen; Zengyuan Yu; Ping Cheng; Zhidan Yu; Weyland Cheng; Wancun Zhang; Zhaobao Wang; Xueyan Gao; Huiqing Sun; Xiaolei Wang
• Keywords: Akkermansia muciniphila

Akkermansia muciniphila is a gram-negative bacterium that colonizes the human gut, making up 3–5% of microbiome. A. promising next-generation probiotic with clinical application prospects. Emerging studies have reported various beneficial effects including anti-cancer, delaying aging, reducing inflammation, improving immune function, regulating nervous system whereas knowledge on its roles and mechanism in infectious disease currently unclear. In this review, we summarized basic characteristics, genome phenotype diversity, influence derived components diseases, such as sepsis, virus infection, enteric periodontitis foodborne pathogen induced infections. We also provided updates mechanisms how protects intestinal barrier integrity modulate host response. summary, believe therapeutic may be applied for treatment variety diseases.