Protective effect of chicken yolk antibody Y against Campylobacter jejuni induced diarrhea in cats

• DOI: 10.3389/fmicb.2024.1378029
• Publication Date: 2024-04-09T15:39:27Z
• Authors: Ziyang Li; Jiayi Yan; Zhaowei Bian; Jie Zhang; Yuwen Liu; Jinping Deng; Baichuan Deng; Sufang Han
• Keywords: Yolk

Campylobacter jejuni (C. jejuni) is a common pathogen that often causes diarrhea, loss of appetite, and even enteritis in domestic cats, affecting their growth development, especially kittens under 6 months age. Oral passive immunization with chicken yolk antibody Y has been proved effective for the treatment gastrointestinal infections due to its high specificity. In this study, C. was isolated from diarrheal cat feces, specific egg against demonstrated effectively inhibit proliferation vitro experiments. To evaluate effect anti- IgY, mouse infection model established it found IgY could alleviate -induced clinical symptoms. Consistent these results, reduction pro-inflammatory factors intestinal colonization by IgY-treated groups, dose group. We then evaluated protective on young Ragdoll cats infected . This reduced rate feline protected inhibited systemic inflammatory hyperactivation, increased fecal short-chain fatty acid concentrations. Notably, may have role changing amino metabolism chemotaxis. Collectively, promising therapeutic strategy diarrhea.