Exercise-Induced Extracellular Vesicles Delay the Progression of Prostate Cancer

• DOI: 10.3389/fmolb.2021.784080
• Publication Date: 2022-01-11T06:05:05Z
• Authors: Lilite Sadovska; Jānis Auders; Laura Keiša; Nadezhda Romanchi...; Laila Silamiķele; Madara Kreišmane; Pawel Zayakin; Satoru Takahashi; Zane Kalniņa; Aija Linē
• Keywords: 0303 health sciences; 03 medical and health sciences; exercise; RNA cargo; QH301-705.5; RNA sequencing; Molecular Biosciences; Biology (General); extracellular vesicles; prostate cancer; 3. Good health

Increasing evidence suggests that regular physical exercise not only reduces the risk of cancer but also improves functional capacity, treatment efficacy and disease outcome in patients. At least partially, these effects are mediated by secretome tissues responding to exercise. The secreted molecules can be released a carrier-free form or enclosed into extracellular vesicles (EVs). Several recent studies have shown EVs actively circulation during Here, we for first time investigated exercise-induced on progression an F344 rat model metastatic prostate cancer. Although did observe consistent increase circulating EV levels, RNA sequencing analysis demonstrated substantial changes content collected before immediately after forced wheel running as well differences between from runners at resting state sedentary rats. major biotype was mRNA, followed miRNA rRNA. Molecular functions differentially expressed RNAs reflected various physiological processes including protein folding, metabolism regulation immune responses triggered parental cells. Intravenous administration rats with orthotopically injected syngeneic cells PLS10, reduction primary tumor volume 35% possibly-attenuation lung metastases. Hence, our data provide may modulate physiology delay