Urine Organic Acids as Metabolic Indicators for Global Developmental Delay/Intellectual Disability in Chinese Children

• DOI: 10.3389/fmolb.2021.792319
• Publication Date: 2021-12-22T08:12:24Z
• Authors: Baiyu Chen; Yalan Zhan; Miriam Kessi; Shimeng Chen; Juan Xiong; Xiaolu Deng; Lifen Yang; Jing Peng; Fei Yin; Fang He
• Keywords: Metabolic pathway; Isoleucine

Objective: The purpose of this study was to search for differential metabolites in urine organic acids, and characterize metabolic features that can be used identify exploration global developmental delay (GDD)/intellectual disability (ID) etiology pathogenesis. Methods: We screened positive test results could explain GDD/ID from 1,253 cases, the major 132 acids 1,230 cases with negative (863 GDD 367 ID cases), 100 typically developing children (TD). Non-supervisory principal component analysis orthogonal partial least squares discriminant were develop models distinguish TD children, detect metabolites. Results: get 23 cause 1253 diagnosed GDD/ID. Among results, we group had same trend compared group. Twenty four obtained group, 25 (VIP > 1.0, p < 0.01). These mainly related following pathways: synthesis degradation ketone bodies, citrate cycle, alanine, aspartate glutamate metabolism, pyrimidine butanoate pyruvate fatty acid biosynthesis, valine, leucine isoleucine degradation. Conclusion: use metabolomics research methods discover metabolites, which might valuable future on etiology, pathogenesis, prognosis possible interventions significantly altered indicators therefore potential diagnostic biomarkers