The Prognostic Value of Lysine Acetylation Regulators in Hepatocellular Carcinoma

• DOI: 10.3389/fmolb.2022.840412
• Publication Date: 2022-03-09T06:09:28Z
• Authors: Liying Sun; Jian Zhang; Kai Wen; Shenglan Huang; Dan Li; Yongkang Xu; Jianbing Wu
• Keywords: Liver Cancer

Background: Hepatocellular carcinoma (HCC) is a tumor with high morbidity and mortality worldwide. lysine acetylation regulators (LARs) dynamically regulate Lysine modification which plays an important regulatory role in cancer. Therefore, we aimed to explore the potential clinical prognostic value of LARs HCC. Methods: Differentially expressed normal liver HCC tissues were obtained from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) datasets. To identify genes establish risk characteristics LARs, consensus clustering was employed. We used univariate Cox regression survival analysis LASSO based on determine independent signature CIBERSORT Gene Set Enrichment Analysis (GSEA) estimate immune infiltration functional enrichment respectively. expression LAR detected by Real-time quantitative polymerase chain reaction (RT-qPCR). statistical analyses conducted using SPSS R software. Results: In this study, 33 data corresponding information TCGA ICGC found majority differentially expressed. Consensus cluster carried out cohort, three subtypes (cluster 1, 2, 3) obtained. LA3 subgroup had worst outcomes. Nine key identified affect prognosis. results showed that has strong patients, whether training datasets or testing GSEA various tumor-related processes pathways abundant high-risk groups. RT-qPCR HAT1, HDAC1, HDAC2, HDAC4, HDAC11 highly cells. Conclusion: Our suggest play critical roles are helpful for individual prognosis monitoring decision-making