Circular RNA and intervertebral disc degeneration: unravelling mechanisms and implications

• DOI: 10.3389/fmolb.2023.1302017
• Publication Date: 2023-12-19T11:05:05Z
• Authors: Guohao Xie; Tingrui Wu; Guangju Ji; Hang Wu; Yue Lai; Bo Wei; Wenhua Huang
• Keywords: Circular RNA; Intervertebral Disc; Degeneration (medical)

Low back pain (LBP) is a major public health problem worldwide and significant economic burden. Intervertebral disc degeneration (IDD) the reason for LBP. However, we have not identified effective therapeutic strategies to address this challenge. With accumulating knowledge on role of circular RNAs in pathogenesis IDD, realised that (circRNAs) may tremendous potential clinical application prospects field. This review presents an overview current understanding characteristics, classification, biogenesis, function circRNAs summarises protective detrimental involved intervertebral been studied thus far. aimed help researchers better understand regulatory progression reveal their potential, provide theoretical basis prevention targeted treatment IDD.