A comprehensive pan-cancer analysis revealing the role of ITPRIPL1 as a prognostic and immunological biomarker

• DOI: 10.3389/fmolb.2024.1452290
• Publication Date: 2024-08-15T04:22:51Z
• Authors: Wenyuan Duan; Wen Tian; Zhongyi Li; Yunsong Liu; Linping Xu
• Keywords: Microsatellite Instability; Immune checkpoint

Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein-Like 1 (ITPRIPL1), a single-pass type I membrane protein located in the membrane, functions as an inhibitory ligand of CD3ε. Recent studies have shown that its expression suppresses T cells activation and promote tumor immune evasion. Despite increasing evidence suggesting ITPRIPL1 plays significant role growth, no systematic pan-cancer analysis has been conducted to date. This study utilized datasets curated from The Cancer Genome Atlas, Genotype Tissue-Expression, Human Protein Atlas investigate relationship between clinical outcomes, infiltration, drug sensitivity across 33 cancer types. We employed multiple methods assess prognostic value pan-cancer, such univariate Cox regression, survival analysis, ROC curve explored mutation burden (TMB), microsatellite instability (MSI), CNV, DNA methylation, immune-related genes, cell reveal immunological role. mRNA levels gene vary significantly types reduced breast cancer. Conversely, high was associated with better prognosis BRCA. Furthermore, highly correlates presence tumor-infiltrating checkpoint genes various cancers. Additionally, TMB 6 MSI 13 High serves protective factor certain types, correlating longer overall Our further confirms participates regulating infiltration affecting patients pan-cancer. These findings underscore promising potential therapeutic target for human