A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice
Superior colliculus
Pars compacta
Pedunculopontine Tegmental Nucleus
Periaqueductal gray
Tegmentum
DOI:
10.3389/fnana.2021.818242
Publication Date:
2021-12-23T08:47:58Z
AUTHORS (12)
ABSTRACT
The glutamatergic and GABAergic neurons in the ventral tegmental area (VTA) substantia nigra pars compacta (SNc) mediated diverse brain functions. However, their whole-brain neural connectivity has not been comprehensively mapped. Here we used virus tracers to characterize inputs outputs of VTA SNc. We found that these received similar from upstream regions, but some quantitative differences were also observed. Neocortex dorsal striatum provided a greater share input neurons. Periaqueductal gray lateral hypothalamic preferentially innervated Specifically, superior colliculus largest SNc Compared patterns, output patterns showed significant preference different regions. Our results laid anatomical foundation for understanding functions cell-type-specific
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (52)
CITATIONS (14)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....