Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease

• DOI: 10.3389/fncel.2022.955511
• Publication Date: 2022-10-20T04:38:29Z
• Authors: Yi Wang; Ping Yuan; Lu Ding; Jie Zhu; Xinrui Qi; Yanyan Zhang; Yunxia Li; Xiaohuan Xia; Jialin C. Zheng
• Keywords: Pathogenesis; Extracellular Vesicles; Extracellular vesicles

The pathogenesis of Alzheimer's disease (AD) remains unknown till today, hindering the research and development AD therapeutics diagnostics. Circulating extracellular vesicles (EVs) can be utilized as a new window to spy upon pathogenesis. Altered microRNA profiles were noted in both cerebrospinal fluid (CSF)- blood-isolated EVs patients, implying outstanding potential circulating EV-containing miRNAs (CEmiRs) serve important regulators Although several CEmiRs found play part AD, association globally altered miRNA patients' serum-derived with unclear. In this study, we first investigated profile from mild cognitive impairment (MCI) healthy individuals. We observed differential expression patterns classified them into 10 clusters. identified predicted targets these differentially expressed (DECEmiRs) analyzed their biological functions interactions. Our study revealed temporal regulation complex precise signaling networks on pathogenesis, shedding light novel therapeutic strategies, including multi-target drug combination for treatment.