Daily Morning Blue Light Therapy for Post-mTBI Sleep Disruption: Effects on Brain Structure and Function

• DOI: 10.3389/fneur.2021.625431
• Publication Date: 2021-02-08T04:35:04Z
• Authors: Adam C. Raikes; Natalie S. Dailey; Brittany Forbeck; Anna Alkozei; William D. S. Kil...
• Keywords: Epworth Sleepiness Scale; Light therapy

Background: Mild traumatic brain injuries (mTBIs) are associated with novel or worsened sleep disruption. Several studies indicate that daily morning blue light therapy (BLT) is effective for reducing post-mTBI daytime sleepiness and fatigue. Studies demonstrating changes in structure function following BLT limited. The present study's purpose to identify the effect of on functional connectivity association between these self-reported change sleepiness. Methods: A total 62 individuals recovering from a mTBI were recruited two US cities participate double-blind placebo-controlled trial. Eligible randomly assigned undergo 6 weeks 30 min placebo amber (ALT). Prior treatment all completed comprehensive battery included Epworth Sleepiness Scale as measure All underwent multimodal neuroimaging anatomical resting-state magnetic resonance imaging. Atlas-based regional gray matter volume (GMV) region-to-region baseline post-treatment primary endpoints this study. Results: After adjusting pre-treatment GMV, receiving had greater GMV than those 15 regions interest, including right thalamus bilateral prefrontal orbitofrontal cortices. Improved was 74 ROIs, covering many same general regions. Likewise, increased both attention cognitive control networks well decreased visual, motor, (all FDR corrected p < 0.05). Conclusions: Following BLT, moderate large increases observed areas previously regulation function, alertness, attention. Additionally, findings improvements Further work needed personal characteristics may selectively whom be optimally beneficial.