Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients

• DOI: 10.3389/fneur.2022.1028864
• Publication Date: 2022-11-21T04:41:07Z
• Authors: Sabeth Becker; Franziska Klein; Katja König; Christian Mathys; Thomas Liman; Karsten Witt
• Keywords: Cerebral autoregulation; Stroke; Acute stroke

Introduction In acute ischemic stroke, progressive impairment of cerebral autoregulation (CA) is frequent and associated with unfavorable outcomes. Easy assessment blood flow CA in stroke units bedside tools like near-infrared spectroscopy (NIRS) might improve early detection deterioration. This study aimed to assess dynamic multichannel CW-NIRS (AIS) patients compared agematched healthy controls. Methods reaction was amplified by changes head bed position. Long- short channels were used monitor systemic artery pressure- intracranial oscillations simultaneously. Gain phase shift spontaneous low- very low-frequency (LFO, VLFO) pressure assessed. Results A total 54 participants, 27 AIS age-matched controls included. significantly lower the group LFO range (i) when upper body steadily elevated 30. (ii) after its abrupt elevation 30°. No other differences found between groups. Discussion demonstrates feasibility NIRS measure one single instrument. gain indicate decreased activity this pilot study, but further studies investigating role are needed.