The Indirect Impact of COVID-19 on Major Clinical Outcomes of People With Parkinson's Disease or Parkinsonism: A Cohort Study

• DOI: 10.3389/fneur.2022.873925
• Publication Date: 2022-05-16T07:51:00Z
• Authors: Luca Vignatelli; Flavia Baccari; Laura Maria Beatr...; Corrado Zenesini; Elisa Baldin; Giovanna Calandra...; Pietro Cortelli; Carlo Descovich; Giulia Giannini; Maria Guarino; Giuseppe Loddo; Stefania Alessand...; Luisa Sambati; Cesa Scaglione; Susanna Trombetti; Roberto D'Alessandro; Francesco Nonino
• Keywords: Parkinson's disease; COVID-19; 3. Good health; 03 medical and health sciences; COVID-19; Parkinson's disease; cohort studies; parkinsonism; physiotherapy; 0302 clinical medicine; cohort studies; Neurology; Neurology. Diseases of the nervous system; RC346-429; parkinsonism; physiotherapy

Background The indirect impact of the COVID-19 epidemic on major clinical outcomes people with Parkinson's disease (PD) or other parkinsonism is unknown. Objectives study aimed to (1) describe changes in healthcare services during first bout PD parkinsonism; (2) compare occurrence hospitalization for any PD-related 2020 2019; (3) investigate factors, including services, associated and death. Methods All province Bologna were assessed through a record linkage (ParkLink Bologna) using data health databases. Same analyses performed random cohort controls matched age, sex, district residence, comorbidities ParkLink (ratio 1:10). Results A subjects (759) (192) was included together (9,226). indicators dropped at least below 50% lockdown period all cohorts, mostly impacting physiotherapy (−93%, 95% CI 88–96%). In 2020, compared 2019, three-fold risk injuries (RR 3.0, 1.5–6.2) infections 3.3, 1.5–7.2), excluding COVID-19, observed only PD, neither nor controls. Decreased one outcome (OR 1.1–9.8) PD. Experiencing strongest factor death 30.4, 11.1–83.4) Conclusions During peak, drastically reduced northern Italy, regardless condition. However, had higher outcomes, that mortality. Strategies maintain physical activity should be implemented possible future emergencies.