Periventricular white matter hyperintensities are associated with gait and balance in patients with minor stroke

• DOI: 10.3389/fneur.2022.941668
• Publication Date: 2022-07-22T16:28:07Z
• Authors: Chen Su; Xiaoyu Yang; Shuqi Wei; Renliang Zhao
• Keywords: Stroke

Cerebral small vessel disease (CSVD) is associated with gait and balance deficits in older adults. However, the effect of CSVD-related brain injury on post-stroke mobility unknown. This study aimed to investigate association CSVD impairment after a minor stroke.A total 273 patients stroke (NIHSS ≤ 5 points) who were hospitalized at Affiliated Hospital Qingdao University enrolled. The manifestations white matter hyperintensities (WMH), lacunes, enlarged perivascular spaces (EPVS), cerebral microbleeds (CMB) statistically analyzed according magnetic resonance imaging results, burden score was calculated. Gait function assessed by 6-m walking speed test, timed-up-and-go (TUG) test. Linear regression analysis applied determine adjusting for key variables.The correlation results showed that stroke, age, sex, smoking history, infarct site speed, age TUG In univariate linear model, periventricular (PVWMH), deep (DWMH), correlated while only PVWMH After confounders, independent predictors (β = -0.089, p < 0.05) test 0.517, 0.05).Our confirmed disorders stroke. are These findings should be larger prospective studies.