Factors contributing to sleep disturbances and excessive daytime sleepiness in patients with Parkinson's disease

• DOI: 10.3389/fneur.2023.1097251
• Publication Date: 2023-03-09T06:52:59Z
• Authors: Keitaro Ogaki; Hiroaki Fujita; Narihiro Nozawa; Tomohiko Shiina; Hirotaka Sakuramoto; Keisuke Suzuki
• Keywords: Epworth Sleepiness Scale; Restless Legs Syndrome; Sleep; Depression

Background Sleep disturbances and excessive daytime sleepiness (EDS) are common non-motor symptoms in patients with Parkinson's disease (PD). The purpose of this study was to identify the contributors sleep disturbances, including insomnia, restless legs syndrome, rapid eye movement behavior disorder (RBD), sleep-disordered breathing, nocturnal akinesia EDS, PD. Methods We conducted a cross-sectional 128 consecutive Japanese EDS were defined as PD Scale-2 (PDSS-2) total score ≥15 an Epworth Sleepiness Scale (ESS) >10, respectively. divided into four groups according presence or absence EDS. evaluated severity, motor symptoms, cognition, olfactory test, Scales for Outcomes PD-Autonomic dysfunction (SCOPA-AUT), Beck Depression Inventory-II (BDI-II), RBD Screening Questionnaire version (RBDSQ-J). Results Of patients, 64 had neither nor 29 without 14 21 both disturbances. Patients higher BDI-II scores than those Probable more frequent SCOPA-AUT lower other three groups. Using multivariable logistic regression analysis reference group, that independent contributor (adjusted OR, 1.192; 95% CI, 1.065–1.333; P = 0.002) (OR, 1.245; 1.087–1.424; 0.001) 1.121; 1.021–1.230; 0.016) RBDSQ-J 1.235; 1.007–1.516; 0.043) well 1.137; 1.006–1.285; 0.040) Conclusions Autonomic associated depressive addition autonomic