Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis

• DOI: 10.3389/fneur.2023.1113954
• Publication Date: 2023-03-02T05:12:54Z
• Authors: Katarzyna Zyla-Ja...; Dorothy A. Walton; Kendra S. Plafker; Susan Kovats; Constantin Georgescu; Richard S. Brush; Madison Tytanic; Martin-Paul Agbaga; Scott M. Plafker
• Keywords: Regimen

Five to eight percent of the world population currently suffers from at least one autoimmune disorder. Despite multiple immune modulatory therapies for demyelinating diseases central nervous system, these treatments can be limiting subsets patients due adverse effects and expense. To circumvent barriers, we investigated a nutritional intervention in mice undergoing experimental encephalomyelitis (EAE), model autoimmune-mediated demyelination that induces visual motor pathologies similar those experienced by people with sclerosis (MS).EAE was induced female male impact dietary carbohydrates feeding ketogenic diet (KD) enriched medium chain triglycerides (MCTs), alpha-linolenic acid (an omega-3 fatty acid), fiber evaluated both preventive regimen (prior immunization MOG antigen) an interventional (following onset symptoms). Motor scores were assigned daily acuity measured using optokinetic tracking. Immunohistochemical analyses optic nerves done assess inflammatory infiltrates myelination status. Fatty cytokine profiling blood performed evaluate systemic status.The KD efficacious when fed as well initiated following symptom onset. The minimally impacted body weight during time course, increased circulating ketones, prevented ocular deficits, preserved nerve, reduced infiltration cells nerves. also anti-inflammatory-associated acids plasma select cytokines circulation associated EAE-mediated pathological inflammation.In light ongoing clinical trials strategies treat MS, findings support MCTs, acids, promotes anti-inflammatory milieu ameliorates autoimmune-induced deficits.