Clinical features of persistent postural-perceptual dizziness with isolated otolith dysfunction as revealed by VEMP and vHIT findings

• DOI: 10.3389/fneur.2023.1129569
• Publication Date: 2023-03-16T05:31:15Z
• Authors: Masato Azami; Hiroaki Fushiki; Reiko Tsunoda; Tomohiko Kamo; Hirofumi Ogihara; Ryozo Tanaka; Takumi Kato
• Keywords: Saccule

Background Persistent postural-perceptual dizziness (PPPD) is a relatively new disease entity, with diagnostic criteria published by the Bárány Society. PPPD often preceded peripheral or central vestibular disorder. It not clear how coexisting deficits due to preceding disorders affect symptoms. Objective This study aimed characterize clinical features of without isolated otolith dysfunction using function tests. Methods The included 43 patients (12 males and 31 females) who were diagnosed completed oculomotor-vestibular Dizziness Handicap Inventory (DHI), Hospital Anxiety Depression Scale (HADS), Niigata Questionnaire (NPQ), Romberg test for stabilometry examined. classified into four categories based on evoked myogenic potential (VEMP) video head impulse (vHIT) results: normal both semicircular canals otoliths (normal), (iOtoDys), canal (iCanalDys), (OtoCanalDys). Results Among PPPD, iOtoDys group was largest (44.2%), followed (37.2%), iCanalDys (9.3%), OtoCanalDys (9.3%). Eight 19 showed abnormal cVEMP oVEMP responses unilaterally bilaterally (both sacculus utriculus damage type), whereas 11 either an response (either type). In three-group comparison type, group, mean total, functional, emotional DHI scores significantly higher type than type. ratio, measure stabilometry, in group. Conclusions coexistence may exacerbate symptoms PPPD. Determining presence extent provide useful information pathophysiology treatment strategies