A study on the correlations between acoustic speech variables and bradykinesia in advanced Parkinson's disease

• DOI: 10.3389/fneur.2023.1213772
• Publication Date: 2023-07-18T15:19:30Z
• Authors: Francesco Cavallieri; Giulia Di Rauso; Annalisa Gessani; Carla Budriesi; Valentina Fioravanti; Sara Contardi; Elisa Menozzi; Serge Pinto; Elena Moro; Francesca Antonelli; Franco Valzania
• Keywords: Finger tapping

Very few studies have assessed the presence of a possible correlation between speech variables and limb bradykinesia in patients with Parkinson's disease (PD). The objective this study was to find correlations different upper extremity under medication conditions advanced PD patients.Retrospective data were collected from cohort before after an acute levodopa challenge. Each patient perceptual-acoustic analysis speech, which included several quantitative parameters [i.e., maximum phonation time (MPT) intensity (dB)]; Unified Disease Rating Scale (UPDRS) (total scores, subscores, items); timed test (a tapping for 20 s) quantify bradykinesia. Pearson's coefficient applied rate.A total 53 [men: 34; duration: 10.66 (SD 4.37) years; age at onset: 49.81 years 6.12)] included. Levodopa intake increased MPT sustained (p < 0.01), but it reduced rate = 0.05). In defined-OFF condition, positively correlated both bilateral mean 0.044, r-value:0.299) left 0.033, r-value:0.314) tapping. defined-ON 0.003), right 0.008).This confirms acoustic patients. These findings suggest common pathophysiological mechanisms.