Association of CLDN molecules with sleep apnea hypopnea syndrome: new biomarker candidates

• DOI: 10.3389/fneur.2024.1347137
• Publication Date: 2024-02-21T05:36:54Z
• Authors: Dan Liu; Han Meng; Nansheng Wan; Jing Feng
• Keywords: Claudin

Introduction Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder, and has become serious threat to public health. Intermittent hypoxia caused by OSA results in low-grade inflammatory response that leads impaired mucosal barrier function. Claudin (CLDN) molecules are important for the permeability of epithelium. This study aimed explore whether CLDN can be potential biomarker OSA. Methods A total 37 healthy controls 40 patients underwent physical assessment filled out STOP-Bang Questionnaire (SBQ) Epworth Sleepiness Scale (ESS). Clinical specimens plasma urine were obtained observe difference between diagnostic accuracy Results CLDN1, CLDN2, CLDN3 decreased (both p < 0.05). The areas under receiver operating characteristic curve (AUCs) urinary CLDN3, 0.887, 0.724, 0.779, 0.676, 0.828, 0.665, respectively. AUC CLDN1 + CLDN2 was 0.906 (95% confidence interval (CI), 0.831–0.981). 0.776 CI, 0.645–0.878). SBQ 0.899 0.832–0.967). ESS 0.896 0.826–0.966). In addition, Urinary CLDN-3 negative associated with severity Conclusion promising as useful biomarkers OSA, which may related function