Relationship between sodium level and in-hospital mortality in traumatic brain injury patients of MIMIC IV database

• DOI: 10.3389/fneur.2024.1349710
• Publication Date: 2024-03-18T04:42:16Z
• Authors: Xiaoliang Wang; Xin Li; Jiahao Sun; Mengmeng Wang; Wenjuan Lang; Xin Xu
• Keywords: Hypernatremia

Background An association between prognosis and high sodium levels in Traumatic Brain Injury (TBI) patients Intensive Care Units (ICUs) has been noted, but limited research exists on the ideal level these or impact early mortality, using MIMIC-IV database. Methods A retrospective survey was conducted TBI from Patients were divided into two categories based their highest serum within 24 h of admission exceeding 145 mmol/L: those with hypernatremia, moderate-to-low levels. Collected covariates encompasses demographic, clinical, laboratory, intervention variables. multivariate logistic regression model implemented to forecast in-hospital mortality. Results The study included 1749 patients, 209 (11.5%) experiencing deaths. non-linear test exposed an L-shaped correlation mortality rates increasing after a turning point at 144.1 mmol/L. Compared group’s 9.3% rate, hypernatremia group had significantly higher rate 25.3% (crude odds ratio = 3.32, 95% confidence interval: 2.37 ~ 4.64, p < 0.001). After adjusting for all covariates, continued show significant risk (adjusted 2.19, 1.38 3.47, This trend remained consistent regardless analyses stratification. Conclusion reveals relationship deaths, pivotal displaying independently linked underlining need further studies targeted management patients.