Stroke-associated pneumonia according to mCDC criteria: impact on prognosis and antibiotic therapy

• DOI: 10.3389/fneur.2024.1358628
• Publication Date: 2024-02-28T05:19:41Z
• Authors: Neus Rabaneda-Lom...; Júlia Faura; Garbiñe Ezcurra-Díaz; Marta Olivé-Gadea; Marta Álvarez-Larruy; Diana Vidal-de Fr...; Ana Domínguez-May...; Carla Avellaneda; Mari Mar Freijo; Elena Zapata-Arriaza; Gemma Serrano-Heras; Cristian Alcahut-...; Isabel Fernández-...; Francisco Moniche; Soledad Pérez-Sán...; Mònica Millán; Marta Rubiera; Laura Dorado; Olga Maisterra; Joan Montaner; Alejandro Bustamante
• Keywords: Stroke; Antibiotic Therapy

Objective The modified Centers for Disease Control and Prevention (mCDC) criteria have been proposed diagnosing managing stroke-associated pneumonia (SAP). objective was to investigate the impact of SAP on stroke outcome depending whether or not it conforms mCDC criteria. Our secondary identify responsible factors antibiotic initiation in patients. Methods We conducted a prospective, multicenter, observational study ischemic patients with moderate severe (NIHSS≥4) admitted within 24 h. For 7 days, were assessed daily, infections antibiotics recorded. Pneumonias divided into those fulfilling (mCDC-SAP) (other pneumonias, OPn). effect each type 3-month evaluated separated logistic regression models. Factors associated explored using random forest analysis. Results Of 342 studied, diagnosed 72 (21.6%), including 39 (11.7%) cases pneumonia. them, 25 (7.5%) fulfilled Antibiotics used 92% mCDC-SAP 64.3% OPn. In analysis, mCDC-SAP, but OPn, an independent predictor poor [OR, 4.939 (1.022–23.868)]. analysis revealed that fever had highest importance initiation. Interpretation might be useful detecting clinically relevant SAP, which is outcomes. Isolated signs infection more important than compliance pre-defined Therefore, adherence result saving without compromising clinical outcome.