Global, regional, and national time trends in the burden of epilepsy, 1990–2019: an age-period-cohort analysis for the global burden of disease 2019 study

• DOI: 10.3389/fneur.2024.1418926
• Publication Date: 2024-08-15T04:38:05Z
• Authors: Tao Shan; Yahui Zhu; Haozhi Fan; Zeye Liu; Jing Xie; Mao Li; Shenqi Jing
• Keywords: Cohort effect

Background Epilepsy is a non-communicable chronic brain disease that affects all age groups. There are approximately 50 million epilepsy patients worldwide, which one of the most common neurological disorder. This study reports time trends in burden from 1999 to 2019. Methods We evaluated and its temporal using prevalence years lived with disability (YLDs), was estimated based on Global Burden Disease (GBD) 2019 study. The age-period-cohort (APC) model used estimate YLDs rates, analyze relative risks age, periods queues (age/period/queue effects). Results In past 30 years, global age-standardized rate has increased by 29.61% 27.02%, respectively. Globally, APC net drift were 0.88% (95% CI: 0.83–0.93) 0.80% 0.75–0.85) per year. Among 204 countries territories, 146 164 showed an increasing trend. And risk increases lowest among 0–4 old highest 75–79 old. Unfavorable period cohort observed. Conclusion Over have gradually globally unfavorable Emphasizing prevention, strengthening health education, optimizing older adults diagnosis treatment plans, actively promoting plans can effectively reduce new cases related disabilities.