The Effect and Optimal Dosage of Dexmedetomidine Plus Sufentanil for Postoperative Analgesia in Elderly Patients With Postoperative Delirium and Early Postoperative Cognitive Dysfunction: A Single-Center, Prospective, Randomized, Double-Blind, Controlled Trial

• DOI: 10.3389/fnins.2020.549516
• Publication Date: 2020-10-23T07:11:01Z
• Authors: Wenshuai Zhao; Yanan Hu; Hui Chen; Xifan Wang; Liping Wang; Yu Wang; Xiaohong Wu; Fei Han
• Keywords: Dexmedetomidine; Postoperative cognitive dysfunction; Sufentanil; Emergence delirium

Background: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common complications among elderly patients after major surgery. Dexmedetomidine (DEX) is less frequently explored for its effects on neurocognitive disorders. This study investigated the effect optimal dosage of DEX patient-controlled analgesia (PCA) POD early POCD Methods: Patients in four groups received continuous infusion 0, 100, 200, 400 μg with sufentanil 150 PCA immediately The were assessed days 1, 2, 3, 7 based Confusion Assessment Method scale Mini-Mental State Examination scale. sedation level, pain intensity, side assessed. trail was registered at Chinese Clinical Trial Registry (ChiCTR-IPD-17010950, Principal investigator, Fei Han, Date registration, March 22, 2017). Results: overall incidence 200 group lower than that 0 100 surgery (P < 0.05). Compared μg, reduced undergoing open There no difference or all groups. Conclusions: significantly decreased without increasing any effects. preferred reducing