A Closed-Loop Optogenetic Platform

• DOI: 10.3389/fnins.2021.718311
• Publication Date: 2021-09-10T14:02:09Z
• Authors: Dimitrios Firfili...; Frances Hutchings; Reza Tamadoni; Darren Walsh; Mark Turnbull; Enrique Escobedo-...; Richard G. Bailey; Johannes Gausden; Aaliyah Patel; Dorian Haci; Yan Liu; Fiona E. N. LeBeau; Andrew Trevelyan; Timothy G. Consta...; Anthony O'Neill; Marcus Kaiser; Patrick Degenaar; Andrew Jackson
• Keywords: Neuromodulation; Interface (matter)

Neuromodulation is an established treatment for numerous neurological conditions, but to expand the therapeutic scope there a need improve spatial, temporal and cell-type specificity of stimulation. Optogenetics promising area current research, enabling optical stimulation genetically-defined cell types without interfering with concurrent electrical recording closed-loop control neural activity. We are developing open-source system provide platform optogenetic neuromodulation, incorporating custom integrated circuitry stimulation, real-time algorithms running on microcontroller experimental via PC interface. include commercial components validate performance, ultimate aim translating this approach humans. In meantime our flexible expandable use in variety preclinical neuroscientific applications. The consists Controlling Abnormal Network Dynamics using (CANDO) Control System (CS) that interfaces up four CANDO headstages responsible through LED optrodes. hardware, inbuilt data acquisition enabled GUI (Graphical User Interface). Here we describe design implementation system, demonstrate how it can be used modulate neuronal oscillations vitro vivo .