A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson’s Disease

• DOI: 10.3389/fnins.2021.763235
• Publication Date: 2021-12-07T13:49:22Z
• Authors: Mattia Arlotti; Matteo Colombo; Andrea Bonfanti; Tomasz Mandat; Michele Maria Lan...; Elena Pirola; Linda Borellini; Paolo Rampini; Roberto Eleopra; Sara Rinaldo; Luigi Romito; Marcus L. F. Janssen; Alberto Priori; Sara Marceglia
• Keywords: Artifact (error); Neurophysiology; Neurostimulation; Interface (matter); Movement Disorders

Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson's disease, dystonia, and essential tremor, has shown clinical benefits in other disorders. A natural path improvement this technique to continuously observe effects on patient symptoms neurophysiological markers. This requires evolution conventional deep stimulators bidirectional interfaces, able record, process, store, wirelessly communicate neural signals a robust reliable fashion. Here, we present architecture, design, first use an implantable sensing interface (AlphaDBSR System) characterized by artifact-free recording distributed data management protocols. Its application three patients with disease (clinical trial n. NCT04681534) as proof functioning clinically viable implanted brain-computer (BCI) adaptive DBS. Reliable artifact free-recordings, chronic long-term signal are place.