Potential dynamic regional brain biomarkers for early discrimination of autism and language development delay in toddlers

• DOI: 10.3389/fnins.2022.1097244
• Publication Date: 2023-01-10T13:51:46Z
• Authors: Shengjuan Wu; Zhi Wen; Wenzhong Yang; Chengcheng Jiang; Yurong Zhou; Zhiwei Zhao; Aiqin Zhou; Xinglian Liu; Xiaoyan Wang; Yue Wang; Hong Wang; Fuchun Lin
• Keywords: Neurotypical; Superior temporal gyrus

Background The early diagnosis of autism in children is particularly important. However, there no obvious objective indices for the spectrum disorder (ASD), especially toddlers aged 1–3 years with language development delay (LDD). differential ASD challenging. Objective To examine differences dynamic characteristics regional neural activity and LDD, whether can be used as an imaging biomarker LDD. Methods Dynamic homogeneity (dReHo) amplitude low-frequency fluctuations (dALFF) 55 31 years, were compared. correlations between symptoms values dReHo/dALFF within regions showing significant between-group analyzed group. We further assessed accuracy alterations to distinguish from LDD using receiver operating characteristic (ROC) analysis. Results Compared group, group showed increased dReHo left cerebellum_8/Crust2 right cerebellum_Crust2, decreased middle frontal gyrus (MFG) post-central gyrus. Patients also exhibited dALFF temporal precuneus. Moreover, Childhood Autism Rating Scale score was negatively correlated cerebellum_8/crust2 cerebellum_crust2. value MFG social self-help Behavior Checklist score. Conclusion pattern resting-state variability different those might novel neuroimaging biomarkers that allow differentiation toddlers.