A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats

• DOI: 10.3389/fnins.2022.889211
• Publication Date: 2022-05-24T13:58:06Z
• Authors: Samuel J. Bowers; Keith C. Summa; Robert S. Thompson; Antonio González; Fernando Vargas; Christopher Olker; Peng Jiang; Christopher A. Lowry; Pieter C. Dorrestein; Rob Knight; Kenneth P. Wright; Monika Fleshner; Fred W. Turek; Martha H. Vitaterna
• Keywords: Prebiotic; Sleep

Sleep disruption is a challenging and exceedingly common physiological state that contributes to wide range of biochemical molecular perturbations has been linked numerous adverse health outcomes. Modern society exerts significant pressure on the sleep/wake cycle via myriad factors, including exposure electric light, psychological stressors, technological interconnection, jet travel, shift work, widespread use sleep-affecting compounds. Interestingly, recent research identified link between microbiome regulation sleep, suggesting interventions targeting may offer unique therapeutic approaches challenges posed by sleep disruption. In this study, we test hypothesis administration prebiotic diet containing galactooligosaccharides (GOS) polydextrose (PDX) in adult male rats improves response repeated during recovery sleep. We found animals fed GOS/PDX for 4 weeks exhibit increased non-rapid eye movement (NREM) rapid (REM) 5 days total time 24 h from compared control diet, despite similar baseline characteristics. Further, led changes fecal microbiome. Consistent with previous reports, relative abundance species Parabacteroides distasonis, which positively correlated parameters Taken together, these findings suggest an approach improve resilience physiologic challenge disruption, part through impacts