Iron quantification in basal ganglia using quantitative susceptibility mapping in a patient with ALS: a case report and literature review

• DOI: 10.3389/fnins.2023.1229082
• Publication Date: 2023-09-28T05:44:23Z
• Authors: Sadegh Ghaderi; Seyed Amir Hossei...; Sana Mohammadi; Farzad Fatehi
• Keywords: Quantitative Susceptibility Mapping; Putamen

Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging (MRI) technique that can measure the of tissues, which reflect their iron content. QSM has been used to detect accumulation in cortical and subcortical brain regions. However, its application regions such as basal ganglia, particularly putamen, rare patients with amyotrophic lateral sclerosis (ALS).We present case 40-year-old male patient ALS who underwent an MRI for QSM. We compared his images those control subject performed quantitative analysis values putamen also reviewed literature on previous studies summarized methods findings. Our revealed increased bilateral controls, indicating overload. This finding consistent reporting dysregulation nuclei ALS. discussed processing techniques our study literature, highlighting advantages limitations.This report demonstrates potential sensitive biomarker evaluating levels patients. provide information deposition patterns both motor extra-motor areas patients, may help understand pathophysiology monitor disease progression. Further larger samples are needed validate these results explore clinical implications