Functional balance at rest of hemispheric homologs assessed via normalized compression distance

• DOI: 10.3389/fnins.2023.1261701
• Publication Date: 2024-01-25T10:04:49Z
• Authors: Annalisa Pascarella; Vittoria Bruni; Karolina Armonaite; Camillo Porcaro; Livio Conti; Federico Cecconi; Luca Paulon; Domenico Vitulano; Franca Tecchio
• Keywords: Magnetoencephalography; Neurophysiology

Introduction The formation and functioning of neural networks hinge critically on the balance between structurally homologous areas in hemispheres. This balance, reflecting their physiological relationship, is fundamental for learning processes. In our study, we explore this functional homology resting state, employing a complexity measure that accounts temporal patterns neurodynamics. Methods We used Normalized Compression Distance (NCD) to assess similarity over time, neurodynamics, somatosensory associated with hand perception (S1). assessment was conducted using magnetoencephalography (MEG) conjunction Functional Source Separation (FSS). Our primary hypothesis posited neurodynamic would be more pronounced within individual subjects than across different individuals. Additionally, investigated whether influenced by hemisphere or age at population level. Results findings validate hypothesis, indicating NCD robust tool capturing balanced hemispheric regions. Notably, observed higher degree left compared right. Also, found intra-subject displayed greater variability older individuals younger ones. Discussion approach could instrumental investigating chronic neurological conditions marked imbalances brain activity, such as depression, addiction, fatigue, epilepsy. It holds potential aiding development new therapeutic strategies tailored these complex conditions, though further research needed fully realize potential.