Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients

• DOI: 10.3389/fnins.2023.1278183
• Publication Date: 2023-10-13T05:57:31Z
• Authors: George Kenefati; Mika M. Rockholt; Deborah Ok; Michael McCartin; Qiaosheng Zhang; Guanghao Sun; Julia Maslinski; Aaron Wang; Baldwin Chen; Erich P. Voigt; Zhe Sage Chen; Jing Wang; Lisa V. Doan
• Keywords: Dorsolateral prefrontal cortex; Cingulate cortex; Alpha (finance)

Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence chronic not only causes hypersensitivity at site injury but may also be associated with pain-aversive experiences anatomically unrelated sites. While animal indicated cingulate prefrontal cortices are involved in this generalized hyperalgesia, mechanisms distinguishing increased sensitivity from site-nonspecific enhancement aversive response to nociceptive inputs well known.We compared measured responses peripheral mechanical stimuli applied pain-free participants suffering lower back (n = 15) versus control by analyzing behavioral electroencephalographic (EEG) data.As expected, endorsed enhanced both hand. We further analyzed recordings during these evoked episodes. Brain oscillations theta alpha bands medial orbitofrontal cortex (mOFC) were localized hypersensitivity, while gamma anterior (ACC) dorsolateral (dlPFC) hyperalgesia.These findings indicate disrupt multiple cortical circuits impact processing.