The causal effect of HbA1c on white matter brain aging by two-sample Mendelian randomization analysis

• DOI: 10.3389/fnins.2023.1335500
• Publication Date: 2024-01-11T05:22:20Z
• Authors: Cheng Tian; Zhenyao Ye; Rozalina G. McCoy; Yezhi Pan; Chuan Bi; Si Gao; Yizhou Ma; Mo Chen; Jiaao Yu; Tong Lu; L. Elliot Hong; Peter Kochunov; Tianzhou Ma; Shuo Chen; Song Liu
• Keywords: Mendelian Randomization

Poor glycemic control with elevated levels of hemoglobin A1c (HbA1c) is associated increased risk cognitive impairment, potentially varying effects between sexes. However, the causal impact poor on white matter brain aging in men and women uncertain.