Time varying characteristic in somatosensory evoked potentials as a biomarker of spinal cord ischemic-reperfusion injury in rat

• DOI: 10.3389/fnins.2024.1411016
• Publication Date: 2024-09-09T05:10:42Z
• Authors: Kai Li; Jianwei Yang; Huaibo Wang; Xuejing Chang; Guanjun Liu; Ruiyang Xue; Weitao Guo; Yong Hu
• Keywords: Somatosensory evoked potential

Spinal cord ischemic-reperfusion injury (SCIRI) could occurs during surgical procedures without detection, presenting a complex course and an unfavorable prognosis. This may lead to postoperative sensory or motor dysfunction in areas innervated by the spinal cord, some cases, permanent paralysis. Timely detection of SCIRI immediate waring can help surgeons implement remedial intervention prevent irreversible injury. Therefore, it is crucial develop precise effective method for early SCIRI. study utilized rat models simulate intraoperative employed somatosensory evoked potentials (SEP) continuous monitoring surgery. In this study, SEP signal changes were examined six groups with varying severities one normal control group. operations different correlated behavioral histopathological data. The result demonstrated specific signals SCIRI, termed as time-varying characteristics, which are associated duration ischemia subsequent reperfusion. Time-varying characteristics potentially serve new biomarker finding significant clinical identify guide timely. Additionally, measurement easily translatable application.