Brain fingerprint and subjective mood state across the menstrual cycle

• DOI: 10.3389/fnins.2024.1432218
• Publication Date: 2024-12-06T06:51:09Z
• Authors: Lorenzo Cipriano; Marianna Liparoti; Emahnuel Troisi L...; Antonella Romano; Laura Sarno; Camille Mazzara; Fabio Alivernini; Fabio Lucidi; Giuseppe Sorrentino; Pierpaolo Sorrentino
• Keywords: self-esteem; brain connectivity; Neurosciences. Biological psychiatry. Neuropsychiatry; menstrual cycle; [SDV] Life Sciences [q-bio]; 03 medical and health sciences; 0302 clinical medicine; well-being; brain fingerprint; depression; brain connectivity; brain fingerprint; depression; menstrual cycle; self-esteem; well-being; RC321-571; Neuroscience

Background Brain connectome fingerprinting represents a recent and valid approach in assessing individual identifiability on the basis of subject-specific brain functional connectome. Although this methodology has been tested validated several neurological diseases, its performance, reliability reproducibility healthy individuals poorly investigated. In particular, impact changes connectivity, induced by different phases menstrual cycle (MC), remains unexplored. Furthermore, although modifications psychological condition women during MC are widely documented, possible link with connectivity Methods We conducted Clinical Connectome Fingerprint (CCF) analysis source-reconstructed magnetoencephalography signals cohort 24 across MC. Results All parameters did not differ according to phases. The peri-ovulatory mid-luteal showed less stable, more variable over time, compared early follicular phase. This difference stability alpha band significantly predicted self-esteem level ( p -value <0.01), mood <0.01) five (environmental mastery, personal growth, positive relations others, purpose life, self-acceptance) six dimensions well-being <0.01, save autonomy). Conclusion These results confirm high CCF as well independence from At same time study provides insights their role affecting women’s subjective state Finally, these share predictive power self-esteem, well-being.