Combination of tauroursodeoxycholic acid, co-enzyme Q10 and creatine demonstrates additive neuroprotective effects in in-vitro models of Parkinson’s disease

• DOI: 10.3389/fnins.2024.1492028
• Publication Date: 2024-12-23T06:42:52Z
• Authors: Alexander Shtilbans; Wolfgang E. Reintsch; Valerio E. C. Pis...; Andrea I. Krahn; Thomas M. Durcan
• Keywords: Tauroursodeoxycholic acid

This study aimed to evaluate different combinations of three dietary supplements for potential additive or synergistic effects in an vitro Parkinson’s Disease model. The complex and diverse processes leading neurodegeneration each patient with a neurodegenerative disorder cannot be effectively addressed by single medication. Instead, various potentially neuroprotective agents targeting disease mechanisms simultaneously may show improved efficacy slowing the progression allowing utilized at lower doses minimize side effects. We evaluated four possible selected supplements: tauroursodeoxycholic acid (TUDCA), co-enzyme Q10 (CoQ10), creatine, chosen their on targets that had previously shown preclinical models. following combinations: (1) TUDCA+CoQ10, (2) TUDCA+Creatine, (3) CoQ10 + Creatine, (4) TUDCA+CoQ10 Creatine. used induced pluripotent stem cell (iPSC) derived human dopaminergic neurons from healthy control, as well microglial cells, effect these neuroinflammation. neurofilament heavy chain, tubulin filament, proinflammatory cytokines metrics. have identified triple combination showed protective across all endpoints. Indeed, could address majority known pathways neurodegeneration, such accumulation misfolded α -synuclein, mitochondrial dysfunction, reactive oxygen species, demonstrated TUDCA, CoQ10, creatine exerts models disease, surpassing compound individually. shows strong candidate further confirmatory studies clinical trials treatment patients with, risk for, disease.