Presence of Tumor Necrosis Factor-Alpha in Urine Samples of Patients With Chronic Low Back Pain Undergoing Chiropractic Care: Preliminary Findings From a Prospective Cohort Study

• DOI: 10.3389/fnint.2022.879083
• Publication Date: 2022-04-12T08:26:27Z
• Authors: Carlos Gevers-Mon...; Mar Romero-Santiago; Lisa Losapio; Francisco Miguel ...; Dave Newell; Luis Álvarez-Galo...; Mathieu Piché; Arantxa Ortega-De...
• Keywords: Alpha (finance)

Low back pain is the leading cause of years lived with disability worldwide. Chiropractors employ different interventions to treat low pain, including spinal manipulative therapy, although mechanisms through which chiropractic care improves are still unclear. Clinical research and animal models suggest that manipulation might modulate plasma levels inflammatory cytokines, have been involved in stages pain. More specifically, serum Tumor Necrosis Factor-alpha (TNF-α) found be elevated patients chronic We aimed investigate whether urine from could an appropriate medium measure concentrations TNF-α examine possible changes its associated care. Urine samples were collected 24 analyzed by ELISA before after 4-6 weeks compared a reference value obtained 5 healthy control subjects, means Welch's t-test. Simultaneously, intensity also evaluated Paired t-tests used compare mean pre post urinary clinical outcomes. Significantly higher baseline observed when our (p < 0.001), significantly lower period treatment = 0.03). Moreover, these accompanied significant reduction (both p 0.001). However, not correlated nor disability. These results good milieu assess changes, potential implications for management