The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines

• DOI: 10.3389/fnut.2022.1066411
• Publication Date: 2022-12-13T04:36:16Z
• Authors: Andhika Rachman; Anggraini Iriani; Dimas Priantono; Bayu Bijaksana Ru...; Rachelle Betsy; Samuel Juanputra
• Keywords: Seroconversion

Introduction During the coronavirus disease 2019 (COVID-19) pandemic, vitamin D has been established as an immune-modulator that reduces pro-inflammatory damage which effectively diminish severity of COVID-19. Vitamin also a significant effect against influenza and dengue increase seroconversion following vaccination. To date, role in optimizing efficacy COVID-19 vaccines remains unclear. This study aimed to analyze correlation between serum 25-hydroxy-cholecalciferol or 25(OH)D levels anti-SARS-CoV-2 S-RBD IgG neutralizing antibody among cancer patients. Methodology A multicenter cross-sectional was conducted solid hematologic patients who were vaccinated with two doses same types (either mRNA, non-replicating viral vector, inactivated) within 6 months. Result The median level 119 36.36 [IQR = 30.30] ng/mL. seropositivity NAb reached 93.3 94.1%, respectively. significantly higher sufficient group (median 414.07 [1,441.83] AU/mL) than deficient 91.56 [652.00] ( p -value 0.049). Among non-chemotherapy subjects, had positive 0.03; R 0.588). showed 0.005; 0.561). positively correlated subjects younger 60 years old 0.047; 0.136). However, 25 (OH)D no such older 0.933; Conclusion Both developed moderate treated without chemotherapy. old. Thus, we recommended maintain above 30 ng/mL (75 nmol/L) enhance vaccines.